Objectives: To determine effectiveness of tadalafil and patient satisfaction after 6 months treatment Design and Methods: The DETECT study is a prospective 12 months European multi-centre observational study in patients with erectile dysfunction(ED) initiating or changing treatment to tadalafil. 236 sites from 8 countries enrolled 1900 eligible patients. Data were available from 1716 patients (90%) and 1582 (83%) after 1 and 6 months with similar baseline characteristics as the initial cohort. 1406 (89%) patients at 6 months reported tadalafil use. International Index of Erectile Function (IIEF) EF domain scores (at each visit) and ED Inventory of Treatment Satisfaction (EDITS) scores (after 1 and 6 months) were analysed for these patients. Results: N=1406 Baseline 1 month 6 months Mean IIEF EF domain score(SD) 14,0(7.3) 24,0(6.1) 24,9(6,0) ED severity (IIEF EF domain score) : -Severe(1-10) 36% 5% 5% -Moderate(11-16) 25% 6% 4% -Mild(17-25) 35% 39% 33% -Normal(26-30) 5% 50% 58% Mean number of sexual attempts in last 4 weeks(SD) 5.0(4.2) 7.1(4.4) 7.3(4.5) Total EDITS satisfaction score 81.0(14.8) 82.9(16.0) Satisfaction (EDITS: very/somewhat satisfied) with : -Treatment overall 86% 89% -Treatment met expectations 75% 80% -How quickly treatment works 87% 90% -How long treatment lasts 87% 89% -Confidence to engage in sexual activity 91% 91% -How satisfied is your partner 81% 83% -Hardness of erections versus before ED 60% 89% Conclusions: 89% of patients reported continued use of tadalafil after 6 months. There was high and sustained improvement in effectiveness and satisfaction in these patients: the percentage with moderate or severe ED decreased from over 60% at baseline to less than 10% at 6 months while the percentage of those in the normal range increased from 5% to nearly 60%.
Conflict of Interest: None disclosed
Financial Support/Funding: Eli Lilly
Sydney Australia, April 2007
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