Introduction and objective; Condyloma acuminata is one of sexually transmitted diseases (STDs) caused by Human Papilloma virus (HPV) which is predominantly found in sexually active group. Various treatments have been recommended by Centre for Diseases Control (CDC). However, some trials have suggested the efficacy of podophyllin against Condylomaacuminata, but there is one trial suggested that podophyllin should be abandoned. So, the objective of this study is to evaluate the effectiveness of podophyllin therapy against Condyloma acuminata. Methods; Retrospective descriptive study was done at Ramathibodi Hospital. Medical records of 186 women who were diagnosed of Condyloma acuminata from January 1998 to December 2005 were reviewed. Patients were weekly received 25% podophyllin applications and were evaluated weekly for 4 weeks. In case of lesions did not regress after 4 weeks of treatment, electrocautery was used for alternative treatment. Main outcome measure was the complete clearance rate. Results; The peak incidence of Condyloma acuminata was being in the age group of 20-30 years with the mean age of 28.3 years. The primary site of the lesions was mostly at perineum(94.1%) and the size was mostly less than 5 mm(76.3). The complete clearance rate was 2.2% at one time application and up to 37.1%, 61.3% and 79.6% after applied 2,3 and 4 times, respectively. When comparing the complete clearance rate with site and size of the lesions, history of STDs and abnormal Pap smear, there were no statistically significance difference. Conclusions; Podophyllin is still effective against Condyloma acuminata with complete clearance rate of 79.6% after 4 times applications. The high success rate in this study may be due to small size of the lesions at the time of starting treatment.
more about this speaker
