Debate about the role of androgens in erection still exists. The aim of this study was to assess the efficacy of long term taking androgen in patients who were previously sildenafil non-responder on demand regime.
Material and methods: In a propective controlled trial 17 patients with ED more than 1 year non-responder on sildenafil taking on demand were included. Average age of patients was 53.4 All patients had late onset hypogonadism (AMS score 37±6, testosterone 7,4±2,3). All patients were treated with Androgel 25 mg. The efficacy of treatment measured by EF domain score on IIEF questionnaire and arterial reponse by Penile Doppler Ultrasound wich were done before treamtent and 2 months later during the treatment. Results: 11/13 patients showed not only improvement the mean score on IIEF (from 8±5 to 14±5, p<0.03) but also improvement in peak systolic velocity up to 16,6%±3 (p<0.04) in the end of 2nd month of treatment. In the end of 1st month only 4/13 showed improvement of erection. Conclusions: It takes time to improve erectile function with androgen therapy.
Conflict of Interest: None disclosed
Financial Support/Funding: The Japan Ministry Of Health, Labour, And Welfare
Sydney, Australia, April 2007
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